O'Halloran Lab

Department of Biological Sciences and Institute for Neuroscience at The George Washington University

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Research

Sodium Calcium Exchangers

NCX-DB: a unified resource for integrative analysis of the sodium calcium exchanger super-family

Bode and O'Halloran, 2018

The NCLX-type Na+/Ca2+exchanger NCX-9 is required for patterning of neural circuits in Caenorhabditis elegans

Sharma et al. 2017

Nematode Sodium Calcium Exchangers: A Surprising Lack of Transport

Sharma and O'Halloran. 2016

Recent structural and functional insights into the family of sodium calcium exchangers

Sharma and O'Halloran. 2014

Analysis of the Na+/Ca2+ exchanger gene family within the phylum Nematoda

He and O'Halloran. 2014

Insight into the family of Na+/Ca2+ exchangers of Caenorhabditis elegans

Sharma et al. 2013
Sensory behavior in C. elegans

Contribution of the cyclic nucleotide gated channel subunit, CNG-3, to olfactory plasticity in Caenorhabditis elegans

O'Halloran et al. 2017

The cyclic nucleotide gated channel subunit CNG-1 instructs behavioral outputs in Caenorhabditis elegans by coincidence detection of nutritional status and olfactory input

He et al. 2016

GCY-8, PDE-2 and NCS-1 are Critical Elements of the cGMP-dependent Thermotransduction Cascade in the AFD Neurons Responsible for C. elegans Thermotaxis

Wang et al. 2013

Nuclear PKG localization is regulated by Go alpha and is necessary in the AWB neurons to mediate avoidance in Caenorhabditis elegans

He and O'Halloran. 2013

Cell- and subunit-specific mechanisms of CNG channel ciliary targeting and localization in C. elegans

Wojtyniak et al. 2013

Defining specificity determinants of cyclic GMP-mediated gustatory sensory transduction in Caenorhabditis elegans

Smith et al. 2013

A comparative study into the molecular evolution of conserved signaling pathway members across olfactory, gustatory, and photo-sensory modalities

He et al. 2013

Investigating the relationship between topology and evolution in a dynamic nematode odor genetic network

Fitzpatrick and O'Halloran. 2012

A Molecular Readout of Long-Term Olfactory Adaptation in C. elegans

He et al. 2012

Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans

O'Halloran et al. 2012

Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation

Lee et al. 2010

Regulators of AWC mediated olfactory plasticity in Caenorhabditis elegans

O'Halloran et al. 2009

Olfactory adaptation behavior in Caenorhabditis elegans

O'Halloran and L'Etoile. 2007
Parasitic Nematodes

Refined ab initio gene predictions of Heterorhabditis bacteriophora using RNA-seq

Vadnal et al. 2018

Identifiication of candidate infection genes from the model entomopathogenic nematode Heterorhabditis bacteriophora

Vadnal et al. 2017

RNAi-mediated gene knockdown by microinjection in the model entomopathogenic nematode Heterorhabditis bacteriophora

Ratnappan et al. 2016

Multiple Lineage Specific Expansions within the Guanylyl Cyclase Gene Family

Fitzpatrick et al. 2006

The chemosensory system of Caenorhabditis elegans and other nematodes. In: Chemical ecology: from genes to ecosystems. Marcel Dicke (Ed.). Springer

O'Halloran et al. 2006

The molecular phylogeny of a nematode specific clade of heterotrimeric G-protein subunit genes

O'Halloran et al. 2006

An investigation of chemotaxis in the insect parasitic nematode, Heterorhabditis bacteriophora.

O'Halloran and Burnell. 2003

Chemoreceptor genes: what can we learn from Caenorhabditis elegans and how we can apply this information to studies on other nematodes?

Burnell and O'Halloran. 2003
Tool Development

fastQ_brew: module for analysis, preprocessing, and reformatting of FASTQ sequence data

O'Halloran, D.M. 2017

phylo-node: A Molecular Phylogenetic Toolkit using Node.js

O'Halloran, D.M. 2017

STITCHER 2.0: primer design for overlapping PCR applications

O'Halloran et al. 2017

A Guide to Using STITCHER for Overlapping Assembly PCR Applications. In: Methods in Molecular Biology, Vol. 1472, Randall Hughes (Ed.): Synthetic DNA. Springer Press

O'Halloran, D.M. 2017

NemaCount: quantification of nematode chemotaxis behavior in a browser

O'Halloran, D.M. 2016

PrimerMapper: high throughput primer design and graphical assembly for PCR and SNP detection

O'Halloran, D.M. 2016

STITCHER: A web resource for high-throughput design of primers for overlapping PCR applications

O'Halloran, D.M. 2015

PrimerView: high-throughput primer design and visualization

O'Halloran, D.M. 2015

A Practical Guide to Phylogenetics for Nonexperts

O'Halloran, D.M. 2014

Multiplex PCR for Identification of Seven Streptococcus pneumoniae Serotypes Targeted by a 7-Valent Conjugate Vaccine

O'Halloran, D.M. and Cafferkey, M.T. 2005

People

Damien O'Halloran

Assistant Professor, Biology

Ramesh Ratnappan

Postdoc, Biology and MITM, 2015-Present

Jonathan Vadnal

Research Assistant, Biology, 2015-Present

Reeham Motaher

Ph.D. candidate, Biology, 2015-Present

Vishal Sharma

Ph.D. candidate, Biology, 2012-2017

Katrin Bode

Ph.D. candidate, Biology, 2017-Present

David Daniel

Undergraduate Researcher, 2014-2016

Julia Keegan

Senior Hons Thesis, Harlan Fellow, 2015-2016

Yoseph Aldras

Senior Hons Thesis, Harlan Fellow, 2013-2015

Isabel Uriagereka-Herburger

High-School Senior, 2016-2017

Chao He

Research Assistant, 2012-2015

Eric Brzozowski

Undergraduate, Luther Rice Fellow, 2012-13

Julian Sacca-Schaeffer

Undergraduate, Harlan Fellow, 2012-2013

Zelda Mendelowitz

Undergraduate Researcher, 2012

Teaching

BISC 2220: Developmental Neurobiology

This course presents a broad description of the principles of neural development across invertebrate and vertebrate species. Spring course, 3 credits

BISC 2320: Neural Circuits and Behavior

This course aims to introduce students to the cellular and molecular properties of neural circuits that form the basis of behavior. Fall course, 3 credits

BISC 4180: Undergraduate Research Seminar

Explore diverse research topics and methods. Fall and Spring course, 1 credit

Contact Us

O'HALLORAN LAB

Adress: 636A Ross Hall, 2300 I Street N.W.

City: Washington DC

E-mail: damienoh[at]gwu[dot]edu


Department and Institute Links:

GWU

Biological Sciences

GWIN